In the Roman era, farmers discovered that planting leguminous crops on large fields in the former had increased production. Therefore, it should be noted that bacteria can enhance the nutrient richness of agricultural soils. Until the 19th century, German alfalfa growers and some American soybean growers, who used land for alfalfa or soybean fields, moved the fields to new inoculants, which increased crop yields. In 1838, French agricultural chemist J.B. Boussingault discovered that legumes can fix nitrogen. It established an agricultural experimental station in 1843, with various crop yields and rotating systems of components for more accurate analysis.

German scientist H. Hellriegal demonstrated in sand cultivation from 1886 to 1888 that only the formation of rhizobia in leguminous plants can fix nitrogen in the atmosphere. In 1888, Dutch scholar M.W. Beijerinck isolated rhizobia, which was a breakthrough in microbial fertilizers. This is now very clear about the role of rhizobia. They discovered that these bacteria prompted an American company to produce and sell Neittel soil bacterial agents in 1898. Since then, there have been many bacteria used in soil preparation, crop mixing, and coating.

In the 1920s, some new soil and field crop microbial agents emerged, but they were not ideal. In the 1940s, the US Department of Agriculture issued licenses for biopesticides, which have been used for over 20 different microbial products for this purpose.

In 1937, Soviet microbiologist Krasynikov and intensive Kinsus developed; ＆rdquo; of Nitrogen fixing bacteria have thus created a precedent for bacterial fertilizers, which for various reasons must halt all mass production of microbial fertilizers. In 1940, Asia developed the use of blue-green algae (algae) as a bio fertilizer for main season rice. Now, it still plays a huge role in sustainable agriculture.

Regardless of the history of biological fertilizers, microbial preparations continue to advance. Since the 1980s, people have devoted great energy and attention to the environment and the use of bio fertilizers in crops, which are the reasons why these products can solve some problems, especially pollution and eliminate environmental pollution. Therefore, developing fertilizers with two functions and the capacity to eliminate environmental pollution is very difficult. The difficulty lies in: (1) having microorganisms that provide plant nutritional functions (such as nitrogen fixing genes, etc.) but do not have the ability to decompose pollution (i.e., the decomposition of material genes). Gene transfer is difficult to achieve, but it is also a huge investment; (2) Various types of soil are pollution-free, and currently there are over 105 substances causing environmental pollution. These pollutants and chemical components are different, so it is impossible to mix 105 microorganisms together to make the formulation. Gene transfer is more difficult to achieve; (3) In addition to biological insecticides and herbicides, the principle of bacteria varies greatly as a principle. Therefore, only a single bacterium was created. And play a long-term role; (4) When biological fertilizers are not typical agents of certain microorganisms, their agents enter the soil and are therefore difficult to survive, usually only before the 3-month shelf life.